Clomid (Clomiphene): a practical guide for fertility and ovulation

Clomid is a common fertility drug used to trigger ovulation. If you're trying to get pregnant or your doctor mentioned clomiphene, this page gives clear, usable info—what it does, how people take it, side effects to watch for, and when to call your clinician.

What it does: Clomid blocks estrogen receptors in the brain so your body thinks estrogen is low. That tells your pituitary gland to release hormones (FSH and LH) that help the ovary release an egg. Most people take it for ovulation problems, including some cases of polycystic ovary syndrome (PCOS) and unexplained infertility.

How people usually take Clomid

Typical dosing is 50 mg once a day for five days, often starting on day 3, 4, or 5 of your menstrual cycle. If ovulation doesn't happen, a doctor may raise the dose to 100 mg. Treatment cycles are usually limited to about 3–6 cycles. Your clinic will track your response with ultrasound or ovulation tests to time intercourse or insemination.

For men, low-dose clomiphene can sometimes help increase testosterone and improve sperm count. That use is off-label and should be monitored by a specialist.

What to expect and common side effects

Most side effects are short term: hot flashes, mood swings, bloating, breast tenderness, and headaches. Some people notice visual changes—blurry vision or floaters—and should stop the drug and call their doctor right away. There's also a small chance of ovarian hyperstimulation (OHSS), which causes severe bloating, pain, and rapid weight gain; seek urgent care if that happens.

Success rates vary. Many people ovulate after Clomid, but not everyone conceives. Clinics often combine ovulation tracking, timed intercourse, or intrauterine insemination (IUI) to improve chances.

Interactions and safety: Tell your doctor about other medications and health conditions. Clomid can interact with thyroid meds and certain hormones. It’s not suitable if you have liver disease, uncontrolled thyroid problems, or unexplained vaginal bleeding. Always follow your provider’s instructions on timing and dose.

Alternatives: Letrozole is another drug used to trigger ovulation and is preferred by some fertility specialists for people with PCOS. Injectable gonadotropins are stronger options when oral drugs don’t work. Your doctor will suggest the best path based on tests and past responses.

Buying and monitoring: Only use Clomid prescribed and supervised by a clinician. Clinics monitor cycles to reduce risks and time treatment properly. Avoid sourcing meds from unverified online sellers—counterfeit or incorrect dosing is a real risk.

Questions to ask your clinician: How many cycles should I try? What are my chances with Clomid given my age and test results? How will you monitor me for ovulation and OHSS? Clear answers here help you make safer, faster decisions.

Need more specifics about dosing, timing, or side effects? Talk with your fertility provider or pharmacist. They’ll tailor the plan to where you are in your cycle and your health history.